Diethylacetamide (DEAC)


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  • Diethylacetamide (DEAC)
  • 685-91-6
  • C6H13NO
  • 115.175
  • clear colorless liquid
Inquiry

Factory Sells Best Quality Diethylacetamide (DEAC) 685-91-6 with steady supply

  • Molecular Formula:C6H13NO
  • Molecular Weight:115.175
  • Appearance/Colour:clear colorless liquid 
  • Vapor Pressure:0.0291mmHg at 25°C 
  • Melting Point:LESS THAN 20ºC 
  • Refractive Index:n20/D 1.440(lit.)  
  • Boiling Point:185.499 °C at 760 mmHg 
  • PKA:-0.41±0.70(Predicted) 
  • Flash Point:69.316 °C 
  • PSA:20.31000 
  • Density:0.873 g/cm3 
  • LogP:0.87470 

Diethylacetamide(Cas 685-91-6) Usage

Synthesis Reference(s)

Chemistry Letters, 18, p. 1983, 1989The Journal of Organic Chemistry, 59, p. 4035, 1994 DOI: 10.1021/jo00094a004

Hazard

Toxic by ingestion.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Flammable when exposed to heat or flame. To fight fire, use foam, mist, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dissolve the amide in cyclohexane, shake with anhydrous BaO and then filter. The procedure is repeated three times, and the cyclohexane is distilled off at atmospheric pressure. The crude amide is also fractionally distilled three times from anhydrous BaO. [Beilstein 4 III 349.]

General Description

N,N-Diethylacetamide is commonly used as drug solvent.

InChI:InChI=1/C6H13NO/c1-3-5(4-2)6(7)8/h5H,3-4H2,1-2H3,(H2,7,8)

685-91-6 Relevant articles

Mechanistic Insights into Fe Catalyzed α-C?H Oxidations of Tertiary Amines

Legacy, Christopher J.,Hope, Taylor O.,Gagné, Yohann,Greenaway, Frederick T.,Frenette, Mathieu,Emmert, Marion H.

, p. 235 - 246 (2020/10/19)

We report detailed mechanistic investiga...

One-Pot Synthesis of Tertiary Amides from Organic Trichlorides through Oxygen Atom Incorporation from Air by Convergent Paired Electrolysis

Luo, Zhongli,Imamura, Kenji,Shiota, Yoshihito,Yoshizawa, Kazunari,Hisaeda, Yoshio,Shimakoshi, Hisashi

, p. 5983 - 5990 (2021/05/04)

A convergent paired electrolysis catalyz...

Production method of N,N-diethyl acetamide

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Paragraph 0018; 0025; 0035; 0045; 0055; 0065; 0075, (2020/06/30)

The invention discloses a preparation me...

Manganese-mediated acetylation of alcohols, phenols, thiols, and amines utilizing acetic anhydride

Jain, Isha,Sharma, Ramandeep,Malik, Payal

supporting information, p. 2952 - 2960 (2019/09/13)

Manganese(II) chloride-catalyzed acetyla...

685-91-6 Process route

diethyl ether
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diethyl ether

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2-chloroethane thioacetate

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2-(diethylamine)ethanethiol

Conditions
Conditions Yield
at 100 ℃;
diethylamine
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1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
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1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate

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Conditions
Conditions Yield
In tetrahydrofuran; at 25 ℃; Rate constant;

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