1-Hydroxyethylethoxypiperazine(HEP)


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  • 1-Hydroxyethylethoxypiperazine(HEP)
  • 13349-82-1
  • C8H18N2O2
  • 174.243
  • yellow-brown oil
Inquiry

Manufacturer supply high quality 1-Hydroxyethylethoxypiperazine(HEP) 13349-82-1 with ISO standards

  • Molecular Formula:C8H18N2O2
  • Molecular Weight:174.243
  • Appearance/Colour:yellow-brown oil 
  • Vapor Pressure:7.57E-05mmHg at 25°C 
  • Refractive Index:n20/D 1.497(lit.)  
  • Boiling Point:267.139 °C at 760 mmHg 
  • PKA:14.41±0.10(Predicted) 
  • Flash Point:115.362 °C 
  • PSA:44.73000 
  • Density:1.077 g/cm3 
  • LogP:-0.83280 

1-Hydroxyethylethoxypiperazine(Cas 13349-82-1) Usage

InChI:InChI=1/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2/p+2

13349-82-1 Relevant articles

Base-Mediated 1,6-Aza-Michael Addition of Heterocyclic Amines and Amides to para-Quinone Methides Leading to Meclizine-, Hydroxyzine-and Cetirizine-like Architectures

Panda, Gautam,Roy, Deblina

, p. 4434 - 4442 (2019)

An expeditious, cost-effective synthetic...

Preparation method of 1-[2-(2-hydroxyethoxy) ethyl] piperazine

-

Paragraph 0031-0064, (2021/02/06)

The invention discloses a preparation me...

New method for preparing quetiapine

-

Paragraph 0020-0021, (2018/04/21)

The invention provides an efficient and ...

13349-82-1 Process route

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
Conditions Yield
With potassium hydroxide; ethanol;
1-[2-(2-hydroxyethoxy)ethyl]piperazine
13349-82-1

1-[2-(2-hydroxyethoxy)ethyl]piperazine

Conditions
Conditions Yield
2-(2-Chlorethoxy)-ethylacetat, 1) Piperazin, 2) KOH;
Aus d. Amin durch Alkyl.;

13349-82-1 Upstream products

  • 120-43-4
    120-43-4

    4-ethoxycarbonylpiperazine

  • 628-89-7
    628-89-7

    2-(2-Chloroethoxy)ethanol

  • 111974-69-7
    111974-69-7

    Quetiapine

  • 111-42-2
    111-42-2

    2,2'-iminobis[ethanol]

13349-82-1 Downstream products

  • 103858-30-6
    103858-30-6

    2-{2-[4-(4-methoxy-benzhydryl)-piperazino]-ethoxy}-ethanol

  • 111974-69-7
    111974-69-7

    Quetiapine

  • 329217-58-5
    329217-58-5

    2-{2-[4-(7-benzyloxy-dibenzo[b,f][1,4]thiazepin-11-yl)-piperazin-1-yl]-ethoxy}-ethanol

  • 329217-60-9
    329217-60-9

    2-{2-[4-(8-benzyloxy-dibenzo[b,f][1,4]thiazepin-11-yl)-piperazin-1-yl]-ethoxy}-ethanol

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